Table 1

Calprotectin concentrations and type of non-steroidal anti-inflammatory drug (NSAID) used

NSAIDNo on NSAIDsAge (y)
(mean (range))
Calprotectin (mg/l) (median (range))No using gastroprotective agentsNo using
PPI H2antagonists Misoprostol 2nd line drug Prednisolone
Diclofenac116 56  (21–79)8.0  (1.0–118.0)1-150 2161549
Naproxen6260 (30–80)9.0 (1.0–60.0)1-150 3933311
Indomethacin35 54 (28–77)7.0 (1.0–60.0)1-150 532213
Ibuprofen3556 (26–75)7.0 (1.0–61.0)1-150 11073
Diclofenac and misoprostol27 60 (24–80)8.0 (1.0–57.0)1-150 0492
Meloxicam763 (50–79)4.5 (0.5–11.0)1-151 02020
Etodolac6 60 (37–74)7.5 (0.5–15.5)1-151 01150
Piroxicam664 (43–77)7.5 (5.0–18.0)1-151 10041
Nabumetone5 58 (46–77)7.0 (4.0–16.0)1-151 00040
Others13 62 (46–71)4.0 (0.5–41.4)1-151 04171
  • 1-150 Significantly different from normals (p<0.0001, Mann-Whitney U test).

  • 1-151 Insufficient patient numbers for reliable statistical analysis.

  • PPI, proton pump inhibitor.