Table 2

Multiple linear regression analysis of variables affecting calprotectin concentrations in 312 patients taking non-steroidal anti-inflammatory drugs (NSAIDs)

Variable	Standard error	95% confidence interval	p Value
Age	0.07	−0.21 to 0.07	0.34
Sex	2.04	−2.38 to 5.67	0.42
Type of NSAID used	0.53	−2.04 to 0.08	0.07
Diagnosis	0.73	−0.75 to 2.13	0.35
Treatment with second line drug	0.62	−1.94 to 0.53	0.26
Treatment with gastroprotective agent	1.40	−1.91 to 3.67	0.54
Treatment with prednisolone	3.25	−6.83 to 5.97	0.90

Second line drugs used included sulfasalazine, methotrexate, gold, penicillamine, azathioprine, hydroxyurea, cyclophosphamide, and chlorambucil.
Gastroprotective agents used included histamine H₂ receptor antagonists, proton pump inhibitors, and misoprostol, as shown in table1.