Small intestinal absorption and permeability in AIDS
| Number | CD4 count (cells ×106/l) | Body mass index (weight/ height2) | 3-O-m-d-glucose (% dose) | d-xylose (% dose) | l-rhamnose (% dose) | Lactulose/ l-rhamnose | |
|---|---|---|---|---|---|---|---|
| Controls | 20 | 26 (2) | 47.5 (11.1) | 31.7 (7.3) | 12.8 (2.6) | 0.03 (0.01) | |
| AIDS, well | 6 | 112 (146) | 21 (3)2-150 | 33.4 (3.0) | 23.3 (3.0)2-152 | 5.0 (1.4)2-152 | 0.04 (0.05) |
| AIDS, weight loss | 11 | 9 (9) | 18 (2)2-152 | 31.5 (17.2) | 12.5 (4.2)2-152 | 3.4 (1.3)2-152 | 0.14 (0.12)2-152 |
| Pathogen negative diarrhoea | 10 | 25 (29) | 19 (3)2-151 | 36.3 (14.6) | 20.5 (12.1)2-152 | 4.7 (2.3)2-152 | 0.15 (0.09)2-152 |
| CMV colitis | 12 | 35 (41) | 20 (4)2-152 | 39.6 (14.3) | 15.5 (6.3)2-152 | 4.2 (1.5)2-152 | 0.20 (0.14)2-152 |
| Microsporidiosis | 11 | 37 (52) | 19 (3)2-152 | 31.7 (16.7) | 13.4 (7.1)2-152 | 3.2 (2.1)2-152 | 0.09 (0.06)2-152 |
| Cryptosporidiosis | 10 | 19 (15) | 18 (4)2-150 | 33.4 (12.4) | 15.9 (7.0)2-152 | 3.7 (1.7)2-152 | 0.15 (0.14)2-152 |
Values presented are mean (SD).
A one way ANOVA was showed significant (p<0.0001) differences in absorption-permeability data between the groups, apart from the 3-O-methyl-d-glucose group.
↵2-150 Differed significantly from controls (p<0.05; Student’st test using Bonferroni’s correction).
↵2-151 Differed significantly from controls (p<0.01).
↵2-152 Differed significantly from controls (p<0.001).
CMV, cytomegalovirus.