Effect of prucalopride on gastric and small bowel transit
| Dose | n | GLAG(min) | GFER(%/min) | SBTT 10% (min) |
|---|---|---|---|---|
| Placebo | 9 | 53 (6) | 0.5 (0.01) | 88 (20) |
| Prucalopride | ||||
| 0.5 mg | 11 | 43 (5) | 0.53 (0.02) | 72 (15) |
| 1 mg | 9 | 53 (8) | 0.53 (0.02) | 69 (17) |
| 2 mg | 11 | 50 (5) | 0.55 (0.02) | 83 (20) |
| 4 mg | 10 | 47 (5) | 0.55 (0.02) | 121 (16) |
Data expressed as mean (SEM).
GLAG = gastric emptying lag time (time for emptying 10% of meal).
GFER = slope of fractional gastric emptying rate.
SBTT = small bowel transit time.