Effect of simvastatin and UDCA on bile acids in gall bladder bile
| Pretreatment | Simvastatin | UDCA | Simvastatin + UDCA | |
|---|---|---|---|---|
| UCA | 0.4 (0.1) | 0.4 (0.1) | 0.5 (0.1) | 0.7 (0.2) |
| UDCA | 2.5 (0.3) | 2.0 (0.3) | 35.2 (5.3)‡ | 47.6 (4.9)‡ § |
| CDCA | 34.0 (2.2) | 33.0 (1.5) | 21.7 (1.8)† | 21.7 (1.9)‡ |
| CA | 41.0 (3.6) | 45.5 (2.5) | 25.8 (3.2)‡ | 17.4 (3.3)‡ ** |
| DCA | 21.2 (2.4) | 18.0 (2.6) | 15.3 (1.2) | 11.4 (2.4)3-150 |
| LCA | 1.0 (0.2) | 1.1 (0.3) | 1.9 (0.2) | 1.5 (0.6) |
| Glyco-conjugated | 70.3 (4.2) | 72.4 (3.2) | 76.6 (7.9) | 84.3 (2.6)† |
| Tauro-conjugated | 29.7 (4.2) | 27.3 (3.1) | 16.2 (1.9)† | 15.6 (2.6)3-150 |
UCA, ursocholic acid UDCA, ursodeoxycholic acid; CDCA, chenodeoxycholic acid; CA, cholic acid; DCA, deoxycholic acid; LCA, lithocholic acid.
↵3-150 p<0.04, †p<0.02, ‡p<0.01 compared with pretreatment; §p<0.04;**p<0.02 compared with UDCA.