Haemodynamic and sodium excretion response following increasing single oral doses of losartan during the dose response study
| Baseline | 2.5 mg | 5 mg | 7.5 mg | 10 mg | |
| Mean arterial pressure (mm Hg) | |||||
| Controls | 96 (3) | 94 (4) | 95 (4) | 97 (4) | 95 (4) |
| Cirrhotic patients | 89 (3) | 85 (3) | 87 (4) | 85 (3) | 74 (1)1-150 † |
| Heart rate (beats/min) | |||||
| Controls | 65 (4) | 69 (3) | 67 (3) | 67 (4) | 69 (4) |
| Cirrhotic patients | 69 (3) | 66 (3) | 64 (4) | 66 (3) | 66 (4) |
| 24 hour urinary sodium excretion (mmol/day) | |||||
| Controls | 184 (19) | 189 (24) | 228 (12) | 210 (21) | 204 (13) |
| Cirrhotic patients | 147 (7)1-150 | 202 (19) | 172 (12) | 203 (10)† | 185 (14) |
↵1-150 p<0.05 versus controls, †p<0.05 versus baseline.