Table 2

Renal sodium handling, systemic and renal haemodynamics, and central blood volume before and after 7.5 mg losartan

Baseline 7.5 mg Losartan
Urinary sodium excretion (mmol/day)
Controls191 (12)206 (16)
 Cirrhotic patients154 (8)2-150 202 (12)
Mean arterial pressure (mm Hg)
Controls95 (3)96 (2)
 Cirrhotic patients88 (3)84 (4)
Heart rate (beats/min)
Controls62 (4)66 (3)
 Cirrhotic patients69 (2)68 (5)
Renal plasma flow (ml/min/1.73 m2)
Controls484 (52)470 (64)
 Cirrhotic patients377 (30)396 (45)
Glomerular filtration rate (ml/min/1.73 m2)
Controls119 (13)101 (9)
 Cirrhotic patients90 (9)92 (11)
Renal vascular resistance (dyne/s/cm5)
Controls8574 (746)8250 (910)
 Cirrhotic patients11843 (1038)10373 (1022)
Central blood volume (ml/m2)
Controls3146 (359)2788 (134)
 Cirrhotic patients3331 (435)3280 (220)
Cardiac index (l/min/m2)
Controls3.43 (0.50)2.92 (0.23)
 Cirrhotic patients3.13 (0.36)2.95 (0.19)
Systemic vascular resistence (dyne/s/cm5)
Controls1264 (133)1264 (111)
 Cirrhotic patients1408 (40)1228 (118)
  • 2-150 p<0.05 versus controls, p<0.05 versus baseline.