Renal sodium handling, systemic and renal haemodynamics, and central blood volume before and after 7.5 mg losartan
| Baseline | 7.5 mg Losartan | |
| Urinary sodium excretion (mmol/day) | ||
| Controls | 191 (12) | 206 (16) |
| Cirrhotic patients | 154 (8)2-150 | 202 (12)† |
| Mean arterial pressure (mm Hg) | ||
| Controls | 95 (3) | 96 (2) |
| Cirrhotic patients | 88 (3) | 84 (4) |
| Heart rate (beats/min) | ||
| Controls | 62 (4) | 66 (3) |
| Cirrhotic patients | 69 (2) | 68 (5) |
| Renal plasma flow (ml/min/1.73 m2) | ||
| Controls | 484 (52) | 470 (64) |
| Cirrhotic patients | 377 (30) | 396 (45) |
| Glomerular filtration rate (ml/min/1.73 m2) | ||
| Controls | 119 (13) | 101 (9) |
| Cirrhotic patients | 90 (9) | 92 (11) |
| Renal vascular resistance (dyne/s/cm5) | ||
| Controls | 8574 (746) | 8250 (910) |
| Cirrhotic patients | 11843 (1038) | 10373 (1022) |
| Central blood volume (ml/m2) | ||
| Controls | 3146 (359) | 2788 (134) |
| Cirrhotic patients | 3331 (435) | 3280 (220) |
| Cardiac index (l/min/m2) | ||
| Controls | 3.43 (0.50) | 2.92 (0.23) |
| Cirrhotic patients | 3.13 (0.36) | 2.95 (0.19) |
| Systemic vascular resistence (dyne/s/cm5) | ||
| Controls | 1264 (133) | 1264 (111) |
| Cirrhotic patients | 1408 (40) | 1228 (118) |
↵2-150 p<0.05 versus controls, †p<0.05 versus baseline.