Frequency of K-ras mutations in different lesions in long standing ulcerative colitis (UC)
| Authors | Carcinoma in UC | Dysplasia | Indefinite for dysplasia | Villous regeneration | Normal + active colitis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| High grade | Low grade | |||||||||||||
| Burmer et al 9 | 1/12 (8) | 0/8 | 0/1 | 0/3 | 0/1 | |||||||||
| Melzeret al 10 | 1/4 (25) | 2/6 (33) | 0/6 | 0/5 | ||||||||||
| Bell et al 11 | 8/33 (24) | 0/8 | 0/5 | |||||||||||
| Chaubertet al 12 | 2/9 (22) | 5/9 (55) | 1/6 (16) | 2/7 (29) | ||||||||||
| Tsuda et al 13 | 1/13 (8) | 0/12 | ||||||||||||
| Chen et al 14 | 2/3 (67) | 4/8 (50) | 0/8 | 0/2 | ||||||||||
| Kern et al 15 5-150 | 3/7 (43) | 1/2 (50) | 1/3 (33) | |||||||||||
| Redston et al 16 5-150 | 3/7 (43) | 4/8 (50) | 1/7 (14) | 5/14 (36) | 0/17 | |||||||||
Percentages are given in parentheses.
↵5-150 Included two patients with long standing Crohn’s disease.