Table 1

Alterations in gastric motility and sensation in functional dyspepsia (FD)

MeasurementMajor findings
Myoelectric activityAlterations in gastric slow waves (tachygastria, bradygastria) in patients with chronic idiopathic nausea and vomiting, and in some patients with FD.
Contractile activityReduced number and/or amplitude of gastric antral pressure waves in 25–40% of a heterogeneous group of patients, including patients with FD; no apparent difference in postprandial antral motility index between Helicobacter pylori positive and negative FD patients; possible decreased frequency of gastric phase 3 of the migrating motor complex in H pylori chronic gastritis; alterations in antroduodenal motor activity normalized after H pylori eradication.
ComplianceGastric compliance normal overall.
Gastric emptyingScintigraphic delay in gastric emptying in 30–75% of patients.
Regional gastric motor dysfunctionAltered intragastric distribution of food (scintigraphy, ultrasonography) in FD; demonstration of a wide gastric antrum in FD (ultrasonography); impaired antral emptying in FD (ultrasonography); impaired proximal gastric accommodation in FD (ultrasonography); impaired duodenogastric reflex in FD (barostat).
Gastric sensitivityHeightened perception of gastric distension in at least 50% of patients with FD.
  • For references to relevant studies, see Chapter 3, tables 4 and 5. In: Drossman D, ed. Rome II: The functional gastrointestinal disorders. McLean, VA: Degnon, 2000 (in press).