Effect of dexamethasone (DEX) and intercellular adhesion molecule (ICAM) 1 expression in several abdominal organs after administration of interleukin (IL) 1β
| Treatment (h post IL-1β) | Liver | Pancreas | Stomach | Jejunum | Ileum | Caecum | Distal colon |
|---|---|---|---|---|---|---|---|
| Control (0) | 2.99 (0.15) | 0.09 (0.01) | 0.09 (0.01) | 0.15 (0.02) | 0.14 (0.02) | 0.12 (0.01) | 0.09 (0.01) |
| IL-1β (2) | 3.83 (0.27) | 0.13 (0.01) | 0.10 (0.01) | 0.19 (0.01) | 0.19 (0.01) | 0.20 (0.02) | 0.12 (0.01) |
| IL-1β (4) | 4.28 (0.41)2-150 | 0.17 (0.02)2-150 | 0.11 (0.01) | 0.22 (0.03)2-150 | 0.22 (0.03)2-150 | 0.16 (0.01) | 0.12 (0.01) |
| + 30 μg/kg DEX (4) | 3.23 (0.21)2-151 | 0.20 (0.02) | 0.12 (0.02) | 0.29 (0.04) | 0.22 (0.40) | 0.18 (0.02) | 0.13 (0.02) |
| + 100 μg/kg DEX (4) | 3.30 (0.20)2-151 | 0.13 (0.01) | 0.09 (0.01) | 0.19 (0.03) | 0.15 (0.01)2-151 | 0.16 (0.01) | 0.10 (0.01) |
Rats (n=5) were left untreated (control group) or were injected intraperitoneally with 20 ng rat IL-1β at time 0. Other animals received DEX at the reported doses subcutaneously one hour prior to IL-1β. Data (mean (SEM)) are reported as percentage of injected dose/g wet tissue.
↵2-150 p<0.05 versus control group (time 0);
↵2-151 p<0.05 versus IL-1β group (4 h).