Guidelines for referral to specialist centres in cases of paracetamol hepatotoxicity
| Day 2 | Day 3 | Day 4 |
| Arterial pH <7.30 | Arterial pH<7.30 | — |
| INR >3 | INR >4.5 | Any rise in INR |
| Encephalopathy | Encephalopathy | Encephalopathy |
| Creatinine >200 μmol/l | Creatinine >200 μmol/l | Creatinine >250 μmol/l |
| Hypoglycaemia |
Day X, day after overdose; INR, international normalised ratio.