King's College Hospital criteria for transplantation in acute liver failure
| Paracetamol |
| • pH <7.30 (irrespective of grade of encephalopathy) or |
| • Prothrombin time >100 seconds and serum creatinine >300 μmol/l if in grade III or IV coma |
| Non-paracetamol |
| • Prothrombin time >100 seconds (irrespective of grade of encephalopathy) or |
| • Any three of the following (irrespective of grade of encephalopathy): |
| (i) aetiology: non-A, non-B (indeterminate) hepatitis, halothane hepatitis, idiosyncratic drug reactions |
| (ii) age <10 or >40 years |
| (iii) jaundice to encephalopathy interval >7 days |
| (iv) prothrombin time >50 seconds |
| (v) serum bilirubin >300 μmol/l |