Immunohistochemical labelling for lamins A/C and B1 in tumour tissues, compared with normal epithelial cells of the same organ
| Lamin A/C | Lamin B1 | ||||||
|---|---|---|---|---|---|---|---|
| Nuclear | Nuclear | ||||||
| Reduced | Absent | Cytoplasmic | Reduced | Absent | Cytoplasmic | ||
| Colonic | |||||||
| Adenoma | 18/18 (100%) | 15/18 (83%) | 7/18 (39%) | 16/18 (89%) | 7/18 (39%) | 5/18 (28%) | |
| Adenocarcinoma | 17/17 (100%) | 14/17 (82%) | 2/17 (12%) | 17/17 (100%) | 7/17 (41%) | 3/17 (18%) | |
| Gastric adenocarcinoma | 7/8 (88%) | 4/8 (50%) | 3/8 (38%) | 6/8 (75%) | 4/8 (50%) | 0/8 (0%) | |
| Oesophageal cancer | |||||||
| Squamous | 3/6 (50%) | 3/6 (50%) | 0/6 (0%) | 3/5 (60%) | 0/6 (0%) | 0/6 (0%) | |
| Adenocarcinoma | 2/2 (100%) | 1/2 (50%) | 0/2 (0%) | 1/2 (50%) | 1/2 (50%) | 0/2 (0%) | |
| Pancreatic cancer | 0/3 (0%) | 0/3 (0%) | 1/3 (33%) | 0/3 (0%) | 0/3 (0%) | 0/3 (0%) | |
| Cervical squamous carcinoma | 3/3 (100%) | 3/3 (100%) | 0/3 (0%) | 2/3 (67%) | 0/3 (0%) | 0/3 (0%) | |
| Uterine adenocarcinoma | 3/3 (100%) | 3/3 (100%) | 0/3 (0%) | 2/3 (67%) | 1/3 (33%) | 0/3 (0%) | |
| Prostate adenocarcinoma | 3/4 (75%) | 0/4 (0%) | 0/4 (0%) | 3/4 (75%) | 0/4 (0%) | 0/4 (0%) | |
| Breast adenocarcinoma | 3/3 (100%) | 0/3 (0%) | 0/3 (0%) | 3/3 (100%) | 0/3 (0%) | 0/3 (0%) | |
| Lung non-small cell carcinoma | 3/3 (100%) | 2/3 (67%) | 0/3 (0%) | 2/3 (67%) | 2/3 (67%) | 3/3 (100%) |
Nuclear lamin expression in neoplastic cells was compared with that found in the nuclei of normal epithelial cells from the same tissue and the data presented as the percentage of cases with reduced and/or absent nuclear lamin expression. Aberrant cytoplasmic expression is also noted as a percentage of neoplastic cases examined.