Table 1

Risk factors and unadjusted odds ratios for adenomas and carcinomas (controls n=238; adenomas n=114; carcinomas n=202)

Risk factorControls
(n (%))
AdenomasCarcinomas
(n (%))OR (95% CI)(n (%))OR (95% CI)
Age ⩾65 years73  (31)65  (57)3.0  (1.9–4.8)119  (59)3.2  (2.2–4.8)
Male sex100 (42)65 (57)1.8 (1.2–2.9)126 (62)2.3 (1.6–3.4)
CRC family history22 (9)10 (9)0.9 (0.4–1.2)23 (11)1.3 (0.7–2.3)
Abdominal pain170 (72)73 (64)0.7 (0.4–1.1)95 (48)0.4 (0.2–0.5)
Blood in stools86 (36)57 (50)1.8 (1.1–2.8)130 (64)3.2 (2.2–4.7)
Constipation5 (2.1)2 (1.8)0.8 (0.2–4.3)9 (4.5)2.2 (0.7–6.6)
Smoking97 (41)66 (58)2.0 (1.3–3.1)101 (50)1.5 (1.0–2.1)
Alcohol208 (87)102 (90)1.2 (0.6–2.5)180 (89)1.2 (0.7–2.1)
Fat diet28 (12)22 (19)1.8 (0.9–3.3)33 (16)1.5 (0.8–2.5)
Anthranoid laxative use33 (14)16 (14)1.0 (0.5–1.9)29 (14)1.0 (0.6–1.8)
Other laxative use8 (3.4)4 (3.5)1.0 (0.3–3.5)7 (3.5)1.0 (0.4–2.9)
Endoscopic melanosis coli7 (2.9)5 (4.4)1.5 (0.5–4.9)8 (4.0)1.4 (0.5–3.8)
Microscopic melanosis coli28 (12)23 (20)1.9 (1.0–3.5)48 (24)2.3 (1.4–3.9)
Low grade microscopic melanosis coli16 (7)16 (14)2.3 (1.1–4.7)38 (19)3.2 (1.7–6.0)
High grade microscopic melanosis coli12 (5)7 (6)1.2 (0.5–3.2)10 (5)1.0 (0.4–2.3)