Changes in neurohumoral factors
| Variable | TIPSS (n=10) | Preascitic cirrhotics (n=10) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| T=0 | T=60 | T=120 | T=150 | T=180 | T=0 | T=60 | T=120 | T=150 | T=180 | ||
| MAP | 108 (5.1) | 101 (4.8) | 101 (3.7) | 104 (2.4) | 105 (3) | 112 (4.3) | 112 (7.4) | 102 (6.6) | 107 (5.2) | 106 (8.1) | |
| HR | 76 (4.3) | 78 (3.1) | 82 (2.9) | 81 (3.9) | 74 (2.2) | 84 (5.1) | 81 (3.1) | 86 (2.1) | 79 (3.0) | 77 (4.5) | |
| FLNa load | 24.1 (5) | 15.1 (3) | 14.2 (4) | 23.9 (2) | 24.6 (6) | 18.1 (1)† | 11 (2.4) | 8.2 (2.5) | 8.9 (2.1)† | 24.5 (6)1-150 | |
| ClNa | 1.1 (0.3) | 1 (0.2) | 1.6 (0.3)1-150 | 2.6 (0.3)1-150 | 2 (0.3)1-150 | 1 (0.2) | 1.6 (0.6) | 1.8 (0.2)1-150 | 1.8 (0.4)1-150 | 2.5 (0.5)1-150 | |
| FENa | 0.9 (0.3) | 1.2 (0.3) | 2.3 (0.9)1-150 | 2 (0.7)1-150 | 1.9 (0.8)1-150 | 1.3 (0.6) | 2.5 (1.4)1-150 | 3.4 (0.9)1-150 | 3.1 (0.9)1-150 | 4 (1.3)1-150 | |
| PRA | 2.5 (0.6) | 1.8 (0.5)1-150 | 1.9 (0.6)1-150 | 2.4 (0.6) | 1.5 (0.4)1-150 | 1 (0.2)1-150 | |||||
| ANGII | 3 (1) | 2 (0.9) | 0.8 (0.6)1-150 | 10 (1)† | 8.6 (1)† | 6.2 (3)1-150 † | |||||
| ANP | 77.5 (17) | 118 (23)1-150 | 90 (21) | 64.7 (20) | 68 (23)† | 52.5 (19) | |||||
| cGMP | 3.9 (0.8) | 4.2 (1) | 4.6 (1.2) | 5.8 (2.2) | 6.8 (2.1) | 4.1 (1.3) | |||||
| NA | 1.5 (0.4) | 1.6 (0.5) | 1.1 (0.3) | 1.2 (0.1) | 1.3 (0.1) | 1 (0.3) | |||||
| ET-1 | 1.9 (0.2) | 1.8 (0.1) | 1.7 (0.1) | 1.5 (0.2)† | 1.5 (0.1)† | 1.4 (0.1) | |||||
Results expressed as mean (SEM).
MAP, mean arterial pressure (mm Hg); HR, heart rate; FLNaload, filtered sodium load (mmol/min); ClNa, sodium clearance (ml/min); FENa, fractional excretion of sodium (%); PRA, plasma renin activity (ng/ml/h); ANGII, angiotensin II (fmol/ml); cGMP, cyclic guanosine monophosphate (nmol/l); NA, noradrenaline (pmol/l); ET-1, endothelin-1 (fmol/l).
↵1-150 p<0.05 compared with baseline, †p<0.05 between the two groups.