Table 2

Changes in neurohumoral factors

VariableTIPSS (n=10)Preascitic cirrhotics (n=10)
T=0T=60T=120T=150T=180T=0T=60T=120T=150T=180
MAP 108  (5.1)101  (4.8)101  (3.7)104  (2.4)105  (3)112  (4.3)112  (7.4)102  (6.6)107  (5.2)106  (8.1)
HR76 (4.3)78 (3.1)82 (2.9)81 (3.9)74 (2.2)84 (5.1)81 (3.1)86 (2.1)79 (3.0)77 (4.5)
FLNa load24.1 (5)15.1 (3)14.2 (4)23.9 (2)24.6 (6)18.1 (1) 11 (2.4)8.2 (2.5)8.9 (2.1) 24.5 (6)1-150
ClNa 1.1 (0.3)1 (0.2)1.6 (0.3)1-150 2.6 (0.3)1-150 2 (0.3)1-150 1 (0.2)1.6 (0.6)1.8 (0.2)1-150 1.8 (0.4)1-150 2.5 (0.5)1-150
FENa 0.9 (0.3)1.2 (0.3)2.3 (0.9)1-150 2 (0.7)1-150 1.9 (0.8)1-150 1.3 (0.6)2.5 (1.4)1-150 3.4 (0.9)1-150 3.1 (0.9)1-150 4 (1.3)1-150
PRA2.5 (0.6)1.8 (0.5)1-150 1.9 (0.6)1-150 2.4 (0.6)1.5 (0.4)1-150 1 (0.2)1-150
ANGII3 (1)2 (0.9)0.8 (0.6)1-150 10 (1) 8.6 (1) 6.2 (3)1-150
ANP77.5 (17)118 (23)1-150 90 (21)64.7 (20)68 (23) 52.5 (19)
cGMP3.9 (0.8)4.2 (1)4.6 (1.2)5.8 (2.2)6.8 (2.1)4.1 (1.3)
NA1.5 (0.4)1.6 (0.5)1.1 (0.3)1.2 (0.1)1.3 (0.1)1 (0.3)
ET-11.9 (0.2)1.8 (0.1)1.7 (0.1)1.5 (0.2) 1.5 (0.1) 1.4 (0.1)
  • Results expressed as mean (SEM).

  • MAP, mean arterial pressure (mm Hg); HR, heart rate; FLNaload, filtered sodium load (mmol/min); ClNa, sodium clearance (ml/min); FENa, fractional excretion of sodium (%); PRA, plasma renin activity (ng/ml/h); ANGII, angiotensin II (fmol/ml); cGMP, cyclic guanosine monophosphate (nmol/l); NA, noradrenaline (pmol/l); ET-1, endothelin-1 (fmol/l).

  • 1-150 p<0.05 compared with baseline, p<0.05 between the two groups.