Effect of h[Gly2]GLP-2 treatment for four or 48 hours on intestinal weight and morphology
| Mouse treatment | Gut weight (g) | Mucosal protein (mg) | Villus height (mm) | Enterocyte width (mm) | Enterocyte length (mm) | MV length (mm) |
| PBS | 1.81 (0.05) | 26.4 (2.0) | 521 (25) | 5.6 (0.2) | 20.6 (0.8) | 1.15 (0.05) |
| h[Gly2]GLP-2 (4 h) | 1.80 (0.03) | 27.2 (1.7) | 512 (14) | 5.5 (0.2) | 23.4 (0.6) | 1.15 (0.06) |
| h[Gly2]GLP-2 (48 h) | 1.76 (0.06) | 28.4 (3.0) | 530 (17) | 5.0 (0.2) | 31.6 (0.9)2-150 | 1.60 (0.06)2-150 |
Mice were injected either once (four hour group) or daily for two days (48 hour group) with 5 μg of h[Gly2]GLP-2.
Values are mean (SEM); n=5 mice per group.
EM measurements were made on 12 photomicrographs per group; MV, microvilli.
↵2-150 p<0.05 compared with phosphate buffered saline (PBS) treated mice (control).