Effect of h[Gly2]GLP-2 treatment for four or 48 hours on intestinal permeability parameters
| Mouse treatment | G (mS/cm2) | n | Cr-EDTA flux (mmol/h/cm2) | n | HRP flux (pmol/h/cm2) | n |
|---|---|---|---|---|---|---|
| PBS | 29.8 (0.8) | 81 | 15.5 (1.1) | 31 | 3.8 (0.5) | 33 |
| h[Gly2]GLP-2 (4 h) | 25.7 (1.7)3-150 | 23 | 10.2 (0.4)3-150 | 9 | 1.6 (0.2)3-160 | 13 |
| h[Gly2]GLP-2 (48 h) | 25.7 (1.4)3-150 | 20 | 11.7 (0.8)3-150 | 11 | 1.3 (0.4)3-160 | 12 |
Mice were injected either once (four hour group) or daily for two days (48 hour group) with 5 μg of h[Gly2]GLP-2.
Values are mean (SEM); n is the number of tissues studied from six mice for h[Gly2]GLP-2 or 33 phosphate buffered saline (PBS) treated mice (control) (combined from all experiments).
↵3-150 p<0.05,
↵3-160 p<0.01 compared with PBS treated control mice.