Endothelial expression of P-selectin (ng of mAb/g tissue) on different organs under basal unstimulated conditions (n=4) or two hours after TNF-α injection, in vehicle or heparin pretreated rats (n=4)
| Lung | Heart | Pancreas | Stomach | Small bowel | Caecum | Colon | Kidney | Muscle | |
|---|---|---|---|---|---|---|---|---|---|
| Basal | 18.2 (6) | 0.1 (0.2) | 0.9 (0.4) | 0.4 (0.1) | 1.2 (0.2) | 1.5 (0.3) | 0.4 (0.2) | −1.1 (0.1) | 0.18 (0.1) |
| TNF/vehicle | 15.3 (8.0) | 3.7 (1.7) | 13.4 (3.1)4-150 | 6.2 (2.1)4-150 | 12.9 (3.1)4-150 | 10.1 (2.4)4-150 | 5.9 (1.4)4-150 | 2.9 (2.2) | 6.2 (1.8)4-150 |
| TNF/heparin | 5.8 (3.9) | 2.3 (0.9) | 11.8 (3.0)4-150 | 4.0 (1.2)4-150 | 12.0 (2.6)4-150 | 9.5 (2.3)4-150 | 5.2 (1.6)4-150 | −3.4 (0.6)4-150 | 4.3 (0.7)4-150 |
↵4-150 p<0.05 v basal.