JNam s | JNas m | JNanet | JClm s | JCls m | JClnet | PD | Isc | G | |
---|---|---|---|---|---|---|---|---|---|
(μEq cm-2 h-1) | (μEq cm-2h-1) | (μEq cm-2 h-1) | (μEq cm-2 h-1) | (μEq cm-2h-1) | (μEq cm-2h-1) | (mV) | (μEq cm-2h-1) | (mS cm-2) | |
Control (n=9) | |||||||||
Basal | 8.56 (0.51) | 1.27 (0.10) | 7.30 (0.47) | 9.61 (0.30) | 6.91 (0.26) | 2.70 (0.31) | −11.8 (1.6) | 4.24 (0.60) | 2.6 (0.1) |
Indomethacin | 7.30 (0.42) | 1.98 (0.27) | 5.31 (0.45) | 10.04 (0.45) | 7.59 (0.56) | 2.45 (0.44) | −9.3 (1.4) | 2.97 (0.48) | 2.3 (0.1) |
p | <0.001 | <0.01 | <0.001 | NS | NS | NS | <0.01 | <0.001 | <0.001 |
Day 3 infected (n=7) | |||||||||
Basal | 7.85 (0.68) | 1.72 (0.16) | 6.14 (0.61) | 8.84 (0.52) | 5.80 (0.32)2-a | 3.04 (0.31) | −8.5 (2.1) | 2.98 (0.74) | 2.6 (0.1) |
Indomethacin | 7.28 (0.54) | 2.35 (0.25) | 4.93 (0.56) | 8.95 (0.45) | 6.11 (0.20)2-a | 2.83 (0.48) | −8.0 (1.5) | 2.60 (0.51) | 2.3 (0.1) |
p | NS | <0.05 | <0.05 | NS | NS | NS | NS | NS | <0.05 |
Day 5 infected (n=7) | |||||||||
Basal | 5.35 (0.29)2-a 2-b | 3.84 (0.23)2-a 2-b | 1.50 (0.33)2-a 2-b | 4.37 (0.60)2-a 2-b | 6.57 (0.33) | −2.20 (0.70)2-a 2-b | −8.9 (1.3) | 3.41 (0.45) | 2.9 (0.1)2-a 2-b |
Indomethacin | 7.03 (0.40) | 4.18 (0.27)2-a 2-b | 2.85 (0.40)2-a 2-b | 5.42 (0.46)2-a 2-b | 4.83 (0.45)2-a | 0.59 (0.47)2-a 2-b | −6.0 (1.0) | 2.32 (0.36) | 2.9 (0.1)2-a 2-b |
p | <0.01 | NS | <0.01 | NS | <0.05 | <0.01 | <0.01 | <0.01 | NS |
Values are mean (SEM).
p, comparison between basal and indomethacin values using the pairedt test; NS, not significant.
PD, potential difference; Isc, short-circuit current; G, conductance; Jm→s, mucosal to serosal flux; Js→m, serosal to mucosal flux.
↵2-a p<0.05 compared with control value for corresponding period;
↵2-b p<0.05 compared with day 3 infected value for corresponding period.