Study | Time of randomisation/ primary therapy | Patients randomised with first bleed (%) | Patients with Child class C cirrhosis (%) | Rebleeding (%) | Mortality (%) | Patients needing “TIPSS rescue” | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ES | TIPSS | ES | TIPSS | ||||||||||||
Cabrera and colleagues1 (TIPSS, n=31; ES, n=32) | <3 days | 68 | 10 | 51 | 23 | 16 | 19 | 28% (9 patients) | |||||||
Rossle and colleagues2 (TIPSS, n=61; ES, n=65) | <24 hours | 39 | 18 | 45 | 15 | 13 | 12 | 14% (9 patients) | |||||||
Cello and colleagues3 (TIPSS, n=24; ES, n=25) | <24 hours | NS | NS | 48 | 12 | 16 | 12 | 24% (6 patients) | |||||||
Sanyal and colleagues4 (TIPSS, n=41; ES, n=39) | ?9–11 days | 44 | 49 | 26 | 24 | 29 | 18 | 21% (8 patients) | |||||||
Jalan and colleagues5 (TIPSS, n=41; ES, n=39)1-150 | 24 hours | 100 | 48 | 52 | 10 | 37 | 42 | 30% (8 patients) | |||||||
Merli and colleagues6 (TIPSS, n=38; ES, n=43) | 3 strata; <1 week, 1–6 weeks, 6 weeks to 6 months | 62 | 12 | 19 | 24 | 19 | 24 | 14% (6 patients) | |||||||
Sauer and colleagues7 (TIPSS, n=42; ES, n=41) | 1–3 days | 100 | 24 | 57 | 23 | 31 | 33 | 12% (5 patients) | |||||||
Garcia-Villareal and colleagues8 (TIPSS, n=22; ES, n=24) | 24 hours | 80 | 30 | 50 | 9 | 33 | 15 | 5% (1 patient, 6 patients died before rescue) |
↵1-150 Endoscopic treatment: variceal band ligation.
TIPSS, transjugular intrahepatic portosystemic stent-shunt; ES, endoscopic sclerotherapy; NS, not stated.