Table 3

Baseline features in responders and non-responders

Responders (n=34)Non-responders (n=73)
Sex (M/F)23/1144/29
Age (years) (mean (SD))8.9 (3.5)8.8 (3.4)
Duration of infection (years)2.5 (1.9)3.2 (2.1)
Source of infection
 HbsAg+ mother11 (32%)24 (33%)
 Household contact11 (32%)35 (47%)
 Other or unknown12 (36%)14 (20%)
ALT (mean (SD))3-152 4.3 (3.0)3-150 2.3 (2.1)3-150
Mean HAI (mean (SD))3-153 4.0 (1.5)3-160 3.1 (1.3)3-160
HBV DNA <1000 pg/ml8/24 (33%)3-151 7/50 (14%)3-151
  • 3-152 Times upper normal value.

  • 3-153 HAI, histological activity index (for scoring system see text).

  • 3-150 p<0.05;

  • 3-160 p<0.02, calculated only for children in the second trial;

  • 3-151 p=0.07, calculated only for children in the second trial.