Effect of physiological (low dose, 0.4 pmol/kg/min) and supraphysiological (high dose, 1.2 pmol/kg/min) doses of GLP-1 on pyloric motility and antro-pyloro-duodenal wave propagation with intraduodenal perfusion of saline or lipid (2.5 kcal/min, 2.5 ml/min)
| Pyloric motility | Antro-pyloro-duodenal propagated contractions (No/60 minutes) | ||||
|---|---|---|---|---|---|
| IPPW (No/10 minutes) | Pyloric tone (mm Hg) | ||||
| Intraduodenal saline | |||||
| Saline iv | 1.6 (0.3) | 0.2 (0.5) | 9.8 (1.3) | ||
| GLP-1 iv: low dose | 10.1 (1.9)3-150 | 5.3 (0.9)3-150 | 0.03-150 | ||
| GLP-1 iv: high dose | 8.6 (1.3)3-150 | 7.3 (1.5)3-150 3-152 | 0.03-150 | ||
| Intraduodenal lipid | |||||
| Saline iv | 14.7 (1.5)3-151 3-154 | 3.1 (0.4)3-151 3-154 | — | ||
| GLP-1 iv: low dose | 15.7 (2.5) | 7.4 (1.0)3-150 3-154 | — | ||
| GLP-1 iv: high dose | 15.5 (2.1) | 8.6 (1.0)3-150 | — | ||
| Saline iv: recovery | 6.2 (1.1)3-150 3-152 3-153 | 5.1 (0.8)3-150 3-152 3-153 | — | ||
Mean (SEM) of actual values (IPPW) and of values over basal (tone) during each 60 minute infusion period; n=11.
For the same intraduodenal perfusion:
↵3-150 p<0.05v saline iv;
↵3-152 p<0.05v low dose GLP-1;
↵3-153 p<0.05v high dose GLP-1. For different intraduodenal perfusions:
↵3-151 p<0.05 v saline iv/intraduodenal saline;
↵3-154 p<0.05 v low dose GLP-1/intraduodenal saline.
IPPW, isolated pyloric pressure waves.