Table 1

Immunostaining of lymphoid and macrophagic cells infiltrating the tumours after thymidine kinase/ganciclovir (TK/GCV) or combined TK/GCV/interleukin 12 (IL-12) or TK/GCV/granulocyte macrophage-colony stimulating factor (GM-CSF) treatments. Shown are the average scores after immunostaining with the different antibodies (arbitrary scale graded from − to +++). In each case, control untreated animals were compared with animals that had received one (day 14), two (day 21), or three (day 27) courses of retrovirus producing cells plus GCV. In treated animals, few biopsies showed any residual tumours and the proportion of tumour free biopsies for each condition is indicated in the first column. Results are given separately for the tumour (T) itself and the stroma (S) corresponding to the corona of inflammatory cells surrounding the tumour