Table 2

Corrected cell counts, expressed as neurone number ×103 per cm2 (data for RD 24 month rats from Johnson and colleagues15)

4–6 monthsAL 16 monthsAL 20months AL 24 monthsRD 24 months DRD 30 months
PGP19.9 (1.1)6.8 (0.65)bd 8.6 (1.6)bd 9.5 (0.5)bd 21.9 (1.1)19.2 (1.1)
(5)(4)(3)(18)(6)(9)
NADH9.7 (0.6)5.0 (0.4)ad 5.1 (0.4)bd 8.1 (0.3)2-c
(20)(6)(12)(33)
ChAT16.3 (0.5)5.7 (0.3)bd 17.4 (1.1)
(4)(4)(4)
NADPH/2.7 (0.1)2.6 (0.4)3.1 (0.4)
 NOS(17)(4)(14)
  • AL, ad libitum; RD, restricted diet; DRD, double restricted diet.

  • 2-a p<0.01,

  • 2-b p<0.001,

  • 2-c p<0.05 compared with young (4–6 month) rats;

  • 2-d p<0.001 compared with RD 24 month rats.

  • Values in italics indicate number of animals.