Frequency of microsatellite instability and target gene mutation
| Mutation at coding region | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| n | MSS2-a | MSI-L2-b | MSI-H2-c | TGFβRII(A)102-d | IGF2R(G)82-e | BAX(G)82-f | hMSH3(A)82-g | hMSH6(C)8h | |
| Hyperplastic polyp | 17 | 15 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Adenoma | 30 | 6 | 8 | 16 | 1 | 2 | 2 | 3 | 4 |
↵2-a MSS (microsatellite stable), no microsatellite instability at nine markers;
↵2-b MSI-L, microsatellite instability at less than 40% of markers;
↵2-c MSI-H, microsatellite instability was present at 40% of markers or more;
↵2-d TGFβRII(A)10, poly(A)10 tract of TGFβ receptor type II gene;
↵2-e IGF2R(G)8, poly(G)8 tract of IGF receptor type 2 gene;
↵2-f BAX(G)8, poly(G)8 tract of BAX gene;
↵2-g hMSH3(A)8, poly(A)8 tract of human MSH3 gene;
hhMSH6(C)8, poly(C) 8 tract of human MSH6 gene.