Frequency and area of basal lymphoid aggregates in the colonic mucosa of ulcerative colitis patients
| Sample ID | Disease classification3-159 | Frequency of aggregates (No/mm2)3-150 | Mean area of aggregates (mm2)3-151 | % of lamina propria occupied by aggregates3-152 |
| UC50 | Severe | 1.4 | 0.07 | 17 |
| UC68 | Severe | 4.9 | 0.03 | 20 |
| UC69 | Severe | 1.8 | 0.08 | 18 |
| UC72 | Severe | 1.5 | 0.14 | 30 |
| UC83 | Severe | 2.5 | 0.14 | 45 |
| UC94 | Severe | 2.2 | 0.28 | 43 |
| Mean (SD) | 2.4 (1.3) | 0.12 (0.09) | 29 (13) | |
| UC55 | Moderate | 1.3 | 0.13 | 17 |
| UC82 | Moderate | 3.8 | 0.04 | 21 |
| UC89 | Moderate | 1.8 | 0.03 | 7 |
| Mean (SD) | 2.3 (1.3) | 0.07 (0.05) | 15 (7) |
↵3-159 Severely diseased tissue: samples had flattened epithelium with low numbers of goblet cells, branched crypts and occasional disruptions. Lamina propria was enlarged and contained numerous leucocytes. Crypt abscesses were often seen. Submucosa was enlarged and contained elevated levels of leucocytes. Moderately diseased tissue: samples had intact epithelium with slightly reduced numbers of goblet cells and no branched crypts. Lamina propria contained increased numbers of leucocytes.
↵3-150 Number of aggregates was counted in an anti-CD45 stained section and the total area of lamina propria in the section was determined by morphometry.
↵3-151 The area of individual aggregates was determined by morphometry in anti-CD45 stained sections.
↵3-152 (Total area occupied by aggregates/total area of lamina propria)×100.