DNA mismatch repair (MMR) protein expression in hereditary non-polyposis colorectal cancer adenomas, familial colorectal cancers (CRC), and sporadic colorectal cancers
| HNPCC adenomas | Familial CRC5-151 | Sporadic CRC | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MSS/MSI-L (n=13) | MSI-H (n=11) | MSS (n=21)5-164 | MSI-H (n=25)5-170 | MSS/MSI-L (n=60) | MSI-H (n=23) | ||||||
| No loss | 6 | 0 | 20 | 2 | 60 | 15-150 | |||||
| hMLH1 loss | 2 | 2 | 0 | 13 | 0 | 21 | |||||
| hMSH2 loss | 5 | 9 | 1 | 10 | 0 | 15-160 | |||||
Loss of MMR protein in MSS/MSI-L lesions: (a) HNPCC adenomav familial CRC (p =0.001, Fisher's exact test); (b) HNPCC adenoma v sporadic CRC (p<0.001, Fisher's exact test).
↵5-151 At least two first degree relatives with CRC;
↵5-164 majority will not be HNPCC;
↵5-170 majority will be HNPCC.
↵5-150 Borderline MSI-L/MSI-H;
↵5-160 aged 34 and adopted (likely HNPCC).