Table 5

DNA mismatch repair (MMR) protein expression in hereditary non-polyposis colorectal cancer adenomas, familial colorectal cancers (CRC), and sporadic colorectal cancers

  • Loss of MMR protein in MSS/MSI-L lesions: (a) HNPCC adenomav familial CRC (p =0.001, Fisher's exact test); (b) HNPCC adenoma v sporadic CRC (p<0.001, Fisher's exact test).

  • 5-151 At least two first degree relatives with CRC;

  • 5-164 majority will not be HNPCC;

  • 5-170 majority will be HNPCC.

  • 5-150 Borderline MSI-L/MSI-H;

  • 5-160 aged 34 and adopted (likely HNPCC).