Dose | Sex (% male) | Age (y) | GE 2 h (%) | GE 4 h (%) | SBTT (min) | Median t1/2 for proximal colonic emptying (min)1-150 |
---|---|---|---|---|---|---|
Placebo (n=14) | 43% | 31 (2) | 53 (3.6) | 88 (2.1) | 170 (18.7) | 30 |
0.05 mg (n=11) | 55% | 31 (3) | 57 (4.4) | 88 (2.6) | 187 (14.6) | 28 |
0.5 mg (n=12) | 17% | 32 (2) | 50 (6.1) | 83 (4.6) | 194 (26.7) | 44 |
5.0 mg (n=11) | 64% | 34 (3) | 57 (5.1) | 94 (2.3) | 211 (18.6) | 40 |
Data are mean (SEM) except as noted.
↵1-150 n=11 for 0.5 mg dose (in one subject the 111In capsule did not dissolve).
GE, gastric emptying; SBTT, small bowel transit time.