Effect of SB-207266 on colonic tone and compliance (mean(SEM))
| Dose | Compliance PR1/2 (mm Hg) | Pre-meal balloon volume (ml) | Post-meal balloon volume (ml) | % Change in tone |
|---|---|---|---|---|
| Placebo (n=14) | 16.0 (0.8) | 125.3 (9.2) | 93.9 (10.2) | 26.2 (5.0) |
| 0.05 mg (n=11) | 17.2 (1.3) | 150.5 (17.7) | 121.0 (16.1) | 17.4 (5.6) |
| 0.5 mg (n=12) | 16.4 (0.7) | 127.7 (16.2) | 102.7 (15.7) | 20.4 (5.0) |
| 5.0 mg (n=11) | 16.6 (0.9) | 141.7 (20.9) | 112.0 (16.7) | 20.8 (2.6) |