Table 4

Effect of SB-207266 on perception of colonic distension (mean (SEM))

Distending pressure (mm Hg)
GasPain
Dose8 mm16 mm24 mm32 mm8 mm16 mm24 mm32 mm
Placebo (n=14)17.6 (4.8)19.8 (4.3)27.4 (5.9)28.4 (5.7)14.6 (3.6)19.6 (4.7)34.9 (7.2)43.1 (7.9)
0.05 mg (n=11)40.3 (8.3)44.5 (8.5)47.5 (8.8)49.2 (8.4)31.5 (8.7)33.8 (8.1)38.5 (9.1)37.7 (9.0)
0.5 mg (n=12)14.4 (5.7)15.5 (6.0)25.3 (5.6)38.8 (5.9)16.8 (5.1)18.5 (6.1)20.9 (6.4)25.3 (7.3)
5.0 mg (n=11)18.0 (5.4)31.7 (7.0)42.9 (7.1)50.2 (6.8)18.0 (6.2)20.4 (5.8)37.1 (8.0)46.6 (9.0)