Table 2

Clinical features of four patients with non-Hodgkin's lymphoma occurring during the course of inflammatory bowel disease

No Sex Age at onset of IBD (y) Age at onset of NHL (y) Interval between IBD-NHL (y) Interval between Tx-NHL (months) Type of IBD Site of IBD Medical therapy of IBD Type of NHL Site/stage of NHL Therapy for NHL Outcome
1M4648217UCExtensiveSalazopyrine, prednisone, methotrexate 1/90–5/90 0.27 g, cyclosporin 5/90–5/91 27 4 gLarge cell diffuse
B cell lymphoma
Mesenteric lymph nodes stage 1ASurgical excisionAlive
2M57614.541UC (PSC)ExtensiveSalazopyrine, prednisone, methotrexate 12/90–5/94 2.73 gLarge pleiomorphic B cell lymphomaCaecal with rectosigmoid involvement stage IVASurgical excisionDied from postop. sepsis
3M4853414UCProctosigmoidSalazopyrine, prednisone, azathioprine 4/94–5/95 57 gMultifocal high grade
B cell lymphoma
Rectum
stage IVA
Surgical excision+ chemotxIn remission for 3 y
4F323429CDTerminal ileumPentasa, prednisone, azathioprine 7/97–4/98 33.7 gLarge cell diffuse B cell lymphomaIleocaecal
stage III
Surgical excision+ chemotxMediastinal recurrence May 1999
  • NHL, non-Hodgkins lymphoma; IBD, inflammatory bowel disease; UC, ulcerative colitis; CD, Crohn's disease; PSC, primary sclerosing cholangitis; chemotx, chemotherapy.