Table 5

Sample size estimates for detecting significant differences

Previous studiesCurrent studies
ParameterCoefficient of variation (%)Difference detectable with 80% power5-a (%)Coefficient of variation (%)5-bDifference detectable with 80% power5-c (%)
Small bowel transit48554145
Colonic transit (GC24)41473943
Colonic meal response43498897
Colonic gas sensation
(mean over 8, 16, 24, 32)		68787380
Colonic pain sensation
(mean over 8, 16, 24, 32)		84967178

  • ↵5-a n=12 v n=12, original sample size planned.

  • ↵5-b n=14 in placebo group.

  • ↵5-c n=14 v n=12 using two samplet test at alpha=0.05.