Table 2

Distribution of CD3+ and CD8+ tumour infiltrating lymphocytes (TILs) in sporadic colorectal cancer, according to level of DNA microsatellite instability (microsatellite instability-high (MSI-H), microsatellite instability-low (MSI-L), and microsatellite stable (MSS))

Variables Total MSI-H (n=32) MSI-L (n=30) MSS (n=40) p Value
CD3 count2-150
 Mean (SD)68.4 (46.9)36.3 (26.5)24.6 (24.1)<0.00012-151
 Median64.525.016.0
CD8 count2-150
 Mean (SD)55.5 (43.4)29.2 (24.6)18.8 (20.4)<0.00012-151
 Median42.020.511.0
TIL
 Negative65 9 (28.1%)21 (70.0%)35 (87.5%)<0.00012-152
 Positive3723 (71.9%) 9 (30.0%) 5 (12.5%)
  • 2-150 Count/1000 tumour nuclei.

  • 2-151 Kruskal-Wallis test.

  • 2-152 χ2 test.