Table 3

Distribution of apoptosis in colorectal cancer according to the level of DNA microsatellite instability (microsatellite instability-high (MSI-H), microsatellite instability-low (MSI-L), and microsatellite stable (MSS))

Variables Total3-151 MSI-H (n=32) MSI-L (n=30) MSS (n=40) p Value
Apoptosis
 Random % (mean (SD))3.55 (1.99)2.52 (1.92)1.53 (1.47)<0.00013-152
 Median3.201.951.15
Surface—apoptosis3-150
 0 (⩽ 1%)181  (3.45%)3  (11.11%)14  (41.18%)<0.00013-152
 + (1–5 %)357 (24.14%)13 (48.15%)15 (44.12%)
 ++ (5–10 %)179 (31.03%)5 (18.52%)3 (8.82%)
 +++ (10–15 %)119 (31.03%)1 (3.70%)1 (2.94%)
 ++++ (>15%)93 (10.34%)5 (18.52%)1 (2.94%)
Growing edge—apoptosis
 0 (⩽ 1 %)417 (21.21%)10 (33.33%)24 (61.54%)0.0023-152
 + (1–5 %)4717 (51.52%)16 (53.33%)14 (35.90%)
 ++ (5–10 %)149 (27.27%)4 (13.33%)1 (2.56%)
Lumen—apoptosis3-160
 0 (little or none)5312 (41.38%)13 (46.43%)28 (71.79%)0.0593-152
 + (some)3412 (41.38%)13 (46.43%)9 (23.08%)
 ++ (widespread)95 (17.24%)2 (7.14%)2 (5.13%)
  • 3-151 Total is the horizontal sum from each of the three MSI subgroups.

  • 3-152 χ2 test.

  • 3-150 Some samples were not available for testing.

  • 3-160 Glandular lumen is not applicable to undifferentiated tumours and therefore these were excluded from this analysis.