First and second rate constants (Tau K1 and K2, respectively) for all proteins followed from a biphasic exponential fit of the data in pericrypt and crypt regions (see materials and methods). Gy50 values were calculated from dose-response curves
| Tau 1/K1 (h) Rate of appearance | Tau 1/K2 (h) Rate of loss | Gy50 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Pericrypt | Crypt | Pericrypt | Crypt | Pericrypt | Crypt | ||||||
| Cytochrome c | 2.0 (0.8) | 1.4 (0.2) | 83.3 (20.8) | 40.0 (4.8) | 3.8 (0.3) | 3.2 (0.2) | |||||
| Caspase | 7.7 (3.0) | 16.7 (5.6) | 76.9 (17.7) | 166.7 (83.4) | 2.3 (0.3) | 1.4 (0.3) | |||||
| Tau 1/K1 (h) Rate of loss | Tau 1/K1(h) Rate of recovery | Gy50 | |||||||||
| Pericrypt | Crypt | Pericrypt | Crypt | Pericrypt | Crypt | ||||||
| OB cadherin | 5.0 (2.8) | — | 58.8 (27.7) | — | 1.3 (0.2) | — | |||||
| SM actin | 16.7 (5.6) | — | 66.7 (22.2) | — | 2.9 (0.5) | — | |||||
| β-catenin | 26.3 (13.8) | 50.0 (15.8) | — | — | 1.6 (0.1) | 1.8 (0.4) | |||||
| E-cadherin | 66.6 (24.8) | 83.3 (64.1) | — | — | 3.3 (0.4) | 3.4 (0.3) | |||||