Table 2

Risk factors for hepatocellular carcinoma in 313 patients with liver cirrhosis

		Cumulative rate of tumour free patients
Variable	p Value	2 y	3 y	5 y
Univariate analysis
Age
<60 y (n=178)		93	78	72
>60 y (n=135)	0.05	93	75	66
Sex
M (n=193)		91	72	64
F (n=120)	<0.02	96	83	77
Child-Pugh class
A (n=198)		95	83	74
B/C (n=115)	<0.001	90	63	60
Hepatits C virus
Positive (n=201)		94	75	63
Negative (n=112)	0.01	96	80	80
Hepatitis B virus
Positive (n=55)		82	74	74
Negative (n=258)	0.06	92	77	73
Ethanol abuse
Positive (n=79)		93	73	72
Negative (n=234)	0.09	93	78	68
Primary biliary cirrhosis
Positive (n=10)		100	87	87
Negative (n=303)	0.03	93	76	68
Cryptogenic cirrhosis
Positive (n=13)		92	92	92
Negative (n=300)	0.03	93	76	68
AFP at entry
<20 ng/dl (n=258)		95	82	72
>20 ng/dl (n=55)	<0.001	79	44	37

Multivariate analysis	Coeff/SE
AFP at entry >20 ng/dl	4.03
Child-Pugh class B/C	3.06
Male sex	2.06