Table 2

Risk factors for nodular and infiltrating hepatocellular carcinoma (HCC) in 370 patients with cirrhosis by Cox proportional hazards regression analysis and the Wald test

Nodular HCCInfiltrating HCC
VariablePt at riskRelative risk(95% CI)pRelative risk(95% CI)p
Age
 ⩽59 y1921
 >59 y1783.1(1.6–5.2)0.0002
Sex
 Males231
 Females139
Duration of cirrhosis
 Diagnosis at inclusion1821
 ⩽3 y1001.3(0.6–2.4)
 > 3 y882.6(1.8–3.4)0.09
Child-Pugh's stage
 A2671
 B1032.5(1.3–4.5)0.002
Alcohol abuse
 Negative339
 Positive31
Anti-HCV
 Negative118
 Positive252
HBsAg
 Negative3201
 Positive503.9(1.1–5.2)0.07
Anti-HCV and HBsAg
 One or both negative3531
 Both positive1716.9(3.8–36.7)0.0007
ALT during follow up
 Normal or <1.51521
 High or fluctuating2-150 2182.2(1.2–4.4)0.03
AFP during follow up
 <20 ng/ml2961
 High or fluctuating2-150 741.7(1.1–3.1)0.09
  • 2-150 Values persistently high or with continuous fluctuations during the whole follow up period of observation.