Table 2

K-ras mutation and p16 methylation according to stage and grade of disease

K-ras mutationp16 alterations
MutatedNot mutatedMethylatedLOH2-aDeletionb
All patients22/4119/4134/418/412/41
 Staging 2-c
  Stage I1111
  Stage II24421
  Stage IIIA11101831
  Stage IIIB2131
  Stage IVA6381
pT category2-c
 pT111
 pT225431
 pT313112141
 pT46381
pN category2-c
 pN017152662
 pN15482
Grading
 G1951131
 G211101741
 G32461
  • 2-a Loss of heterozygosity.

  • 2-b Homozygous deletion.

  • 2-c Accoding to UICC-TNM classification.14