Table 1

Summary of randomised controlled trials (RCTs) of irritable bowel syndrome: clinical effectiveness studies

  • DB, double blind; XO, crossover; DD, double dose.

  • 1-150 No of patients who completed the study;

  • 1-160 constipation predominant patients;

  • 1-165 diarrhoea predominant patients.

  • 1-151 Patients had become completely asymptomatic for 4–6 weeks before entering the study .