Summary of studies evaluating primary sclerosing cholangitis (PSC) as a risk factor for colorectal neoplasia in chronic ulcerative colitis (UC)
| Study | UC case group (No) | Centre | End point (No) | Matched controls | Colectomy rate | Is PSC a risk factor? |
| Broomé 199214 | Dys (17) | Huddinge, Sweden | PSC (5) | Yes | 0% | Yes |
| D'Haens 199316 | Dys (29) | Chicago, USA | Cholestasis/PSC (10) | Yes | 0% | Yes |
| Broomé 199517 | PSC (40) | Huddinge, Sweden | CRC/Dys (15) | Yes | 30% | Yes |
| Brentnall 199618 | PSC (20) | Seattle, USA | Dys (9) | No | 0% | Yes |
| Leidenius 199719 | PSC (45) | Helsinki, Finland | CRC/Dys (13) | Yes | 29% | Yes |
| Marchesa 199720 | PSC (27) | Cleveland, USA | CRC (4)/Dys (14) | Yes | All postop | Yes |
| Shetty 199921 | PSC (132) | Cleveland, USA | CRC (17)/Dys (16) | No | 0% | Yes |
| Harewood 199922 | PSC (110) | Mayo Clinic, USA | CRN (35) | No | n/s | Yes |
| Choi 199225 | PSC (5) | Lahey Clinic, USA | CRC/Dys (2) | No | n/s | No |
| Gurbuz 199526 | PSC (35) | Johns Hopkins, USA | CRC/Dys (13) | No | 3% | Unclear |
| Loftus 199623 | PSC (143) | Mayo Clinic, USA | CRC (8) | No | 37% | No |
| Nuako 199824 | CRC (171) | Mayo Clinic, USA | PSC (30) | Yes | 14% | No |
CRC, colorectal cancer; CRN, colorectal neoplasia; Dys, dysplasia; n/s, not specified.