Test agents used: activity against cyclooxygenase and doses used. Comparison of the relative COX-l and COX-2 activity of each test agent, as well as the methodological information regarding doses and number of animals used
| Activity against cyclooxvlyenase1-a | |||
| Test agent | ID50COX-2/ID50 COX-1 | n | Dose (mg/kg/day) |
| Sulindac | 30 | 10 | 20 |
| Indomethacin | 22–60 | 10 | 2 |
| Meloxicam | 0.07–0.3 | 10 | 0.6 |
| Celecoxib | <0.0008 | 81-b | 6 |
| Sulindac sulphone | — | 10 | 40 |
↵1-a While absolute ID50 values vary according to the cell system used, the ratio stays relatively constant, as does ranking.17 ,22 ,51-55
↵1-b Two animals from this group died after randomisation, one while being anaesthetised for blood collection, and the other had a large gastroduodenal tumour eroding his liver and hepatic vessels.