Table 3

Single point logarithm of odds (LOD) scores and transmission disequilibrium test (TDT) results for the loci on chromosome 3. Single point LOD scores were obtained using Mapmaker/Sibs. TDT statistics were obtained from Genehunter 2.0. Nominal TDT results are only quoted for p values less than 0.01; for two locus TDT tests, values are noted in the row of the first marker (for example, the value of 0.004 quoted for D3S2338 refers to the haplotype D3S2338-D3S3726). The markers used also in the genome wide scan are indicated in italics. The most significant findings for single point and two point TDT analysis are indicated in bold type

		Two point MLS
Marker	Theta^3-a	UC	CD	All	1 locus	2 loci
IL5RA	0.025	0.00	0.96	0.09
D3S3706	0.064	0.05	0.29	0.71
D3S1304	0.043	0.00	0.20	0.28
D3S3591	0.061	0.00	1.30	0.90
D3S1263	0	0.00	0.30	0.00
D3S3680	0.011	0.00	0.02	0.00
D3S1259	0.006	0.00	0.07	0.00
D3S3693	0.026	0.00	0.09	0.00
D3S3608	0.031	0.00	0.00	0.44
D3S1255	0.024	0.00	0.04	0.02
D3S2338	0.019	0.00	0.00	0.00		0.004 (all)
D3S3726	0.063	0.27	0.11	0.10
D3S2336	0.019	0.38	0.28	0.44
D3S2337	0.024	0.00	0.05	0.10		0.004 (all)
D3S1266	0.011	0.00	0.04	0.04		0.004 (CD)
D3S1283	0.025	0.00	0.01	0.01
D3S3547	0.009	0.00	0.28	0.32		0.002 (all)
D3S3727	0.008	0.01	0.23	0.39
D3S1211	0.037	0.25	0.09	0.17
D3S3518	0.015	0.28	0.10	0.26
D3S1277	0.034	0.12	0.05	0.31
D3S1298	0.019	0.36	0.22	0.23
D3S3527	0.004	0.31	0.47	0.57
D3S3521	0.006	0.70	0.30	0.79
AFM206zf2	0.026	0.28	0.05	0.05
D3S3624	0.012	0.87	0.44	0.95
AFMb362wb9	0.004	0.00	0.00	0.00
CCR2	0	0.00	0.23	0.00		0.004 (CD)
CCR5	0.016	0.00	0.19	0.00		0.003 (all)
D3S1076	0.012	0.42	0.05	0.16	0.009(all)
D3S1289	0.073	0.00	0.40	0.11		0.0009(all)
D3S1300	0.089	0.00	0.57	0.30		0.006 (all)
D3S1285	0.065	0.02	0.01	0.09
D3S1566	0.092	0.01	0.08	0.15
D3S3653	0.084	0.32	0.27	0.64
D3S1271	0.117	0.03	0.46	0.26
D3S1278	0.088	0.03	0.78	0.16
D3S1267	0.09	0.00	1.06	0.13
D3S1292	0.092	0.20	0.27	0.35
D3S1569	0.119	0.11	0.60	0.88
D3S1279	0.142	0.12	0.14	0.23
D3S1565	0.138	0.00	0.41	0.10
D3S1602	0.067	0.23	0.00	0.00
D3S1580	0.171	0.19	0.91	0.46		0.008 (all)
D3S1311	—	0.26	0.55	0.28

↵3-a Marker distances were calculated from the families analysed using the program Multimap.30
Theta is the recombination fraction between two markers—that is, 0.025 corresponds to 25 recombination events in 1000 meioses. For small thetas the map distance in morgans is nearly identical to the theta—that is, 0.025=0.025 morgans=2.5 cM.