Markers | Sib pair analysis | TDT test p value | HRR analysis p value | ||||||
---|---|---|---|---|---|---|---|---|---|
Mean proportion of alleles shared | p Value | ||||||||
D12S352 | 0.55 | 0.13 | 0.50 | 0.50 | |||||
D12S1685 | 0.59 | 0.02 | 0.50 | 0.50 | |||||
D12S336 | 0.50 | 0.50 | 0.50 | 0.50 | |||||
D12S77 | 0.50 | 0.50 | 0.35 | 0.50 | |||||
D12S364 | 0.51 | 0.35 | 0.31 | 0.50 | |||||
D12S1596 | 0.50 | 0.50 | 0.17 | 0.50 | |||||
D12S345 | 0.50 | 0.50 | 0.50 | 0.50 | |||||
D12S85 | 0.50 | 0.50 | 0.36 | 0.50 | |||||
D12S368 | 0.51 | 0.44 | 0.50 | 0.50 | |||||
D12S83 | 0.51 | 0.35 | 0.50 | 0.50 | |||||
D12S1676 | 0.51 | 0.35 | 0.26 | 0.50 | |||||
D12S92 | 0.50 | 0.47 | 0.38 | 0.50 | |||||
D12S326 | 0.50 | 0.50 | 0.50 | 0.50 | |||||
D12S351 | 0.50 | 0.50 | 0.17 | 0.50 | |||||
D12S346 | 0.50 | 0.50 | 0.14 | 0.50 | |||||
D12S78 | 0.50 | 0.50 | 0.28 | 0.50 | |||||
D12S79 | 0.52 | 0.26 | 0.04 | 0.50 | |||||
D12S86 | 0.54 | 0.15 | 0.39 | 0.50 | |||||
D12S324 | 0.50 | 0.50 | 0.50 | 0.50 |
Results were obtained using 95 multiplex families with Crohn's disease (CD) for the sib pair analysis and 170 CD multiplex and simplex families for the transmission disequilibrium (TDT) and haplotype relative risk (HRR) tests. Analyses were performed with the Analyze package version 3.0.17 For the 19 markers of chromosome 12, p values of the linkage (sib pair analysis) and association (TDT and HRR analyses) tests are indicated. The marker D12S83 which previously demonstrated a positive linkage and association7 10 11 is in bold.