Intestinal absorption and permeability before and after nimesulide and naproxen (mean (SEM) and [median]) (n=23)
| Nimesulide | Naproxen | Nim-Nap | |||||
|---|---|---|---|---|---|---|---|
| Test substance | Baseline | Day 10 | Baseline | Day 10 | Day 10 | p Value4-150 | |
| 3-o-m-d-glucose (%) | 46 (2.9) [45] | 41 (2.2) [44] | 46 (2.2) [47] | 41 (2.4) [42] | −0.0 (2.8) [−1.2] | 0.8328 | |
| d-xylose (%) | 28 (1.5) [28] | 27 (1.2) [26] | 29 (1.3) [30] | 27 (1.6) [28] | −0.4 (2.0) [−2.8] | 0.9410 | |
| l-rhamnose (%) | 8.4 (0.5) [8.5] | 8.0 (0.4) [8.0] | 9.0 (0.7) [9.5] | 8.8 (0.7) [8.4] | −0.8 (0.7) [−0.8] | 0.5658 | |
| Lactulose/l-rhamnose | 0.028 (0.0) [0.023] | 0.027 (0.0) [0.029] | 0.032 (0.01) [0.025] | 0.042 (0.01) [0.034] | −0.015 (0.01)4-150[−0.007] | 0.1070 |
↵4-150 Koch test, treatment effect.