Table 1

Comparison of intrinsic and extrinsic afferent innervation of the mucosa

Intrinsic afferentExtrinsic afferent
Cell bodiesSubmucosal or myenteric plexusNodose or DRG
Receptive fields8–10 mm2 Similar
DensityOverlappingSparse
Sensitivity to 5-HTYesYes
ModalityMechano- and chemo-sensitivityMechano- and chemo-sensitivity
  • 5-HT, 5-hydroxytryptamine; DRG, dorsal root ganglion.