Effect of interleukin 1β (IL-1β) and omeprazole on gastric acid secretion
| Acid secretion (μEq/4 h) | Volume (ml/4 h) | ||||
|---|---|---|---|---|---|
| 0 h | 20 h | 0 h | 20 h | ||
| Control | 277.5 (62.2) | 279.3 (29.1) | 4.1 (0.5) | 4.7 (0.4) | |
| OPZ | 119.5 (7.2)2-160 | 58.2 (16.5)2-160 | 2.8 (0.2)2-160 | 2.0 (0.1)2-160 | |
| IL-1β | 98.3 (11.6)2-160 | 295.2 (100.8) | 2.0 (0.1)2-160 | 4.3 (1.0) | |
| IL-1β+OPZ | 52.3 (13.5)2-160 | 43.8 (8.3)2-160 | 1.8 (0.2)2-160 | 1.6 (0.2)2-160 | |
Rats received an intraperitoneal injection of 1 μg/kg IL-1β or vehicle and the pylorus was ligated 0 or 20 hours after injection. Omeprazole was administered 20 hours before and four hours after injection of IL-1β or vehicle
↵2-160 p<0.01 compared with controls.
OPZ, omeprazole.