Phenotypic frequencies of TNF2 , DRB14-1500301(DR3), and B8 in all PSC patients and local controls
| Norwegians | British | Combined data | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PSC patients4-151 | Controls4-151 | OR (95%CI) | pcorr | PSC patients4-152 | Controls4-152 | OR (95%CI) | pcorr | Combined OR4-150 | Combined (χ2 1 df)4-150 | Probability pcorr (χ2 1 df)4-150 | Heterogeneity (χ2 2df)4-150 | |||
| TNF2 G→A | 63 (57) | 34 (31) | 3.0 (1.7–5.4) | 0.001 | 34 (68) | 12 (34) | 3.9 (1.6–9.2) | 0.03 | 3.2 (1.8–4.5) | 24.76 | 1 x 10-5 | 0.3 | ||
| DRB14-150030 1 | 59 (54) | 21 (19) | 4.8 (2.5–9.4) | 1×10−6 | 20 (40) | 8 (23) | 2.2 (0.7–6.7) | 0.2 | 3.80 (2.3–6.3) | 27.40 | 1 x 10-6 | 2.01 | ||
| B8 | 22 (51) | 25 (23) | 3.7 (1.6–8.5) | 0.01 | 26 (52) | 9 (26) | 3.0 (1.1–8.9) | 0.055 | 3.41 (1.9–5.9) | 19.08 | 1 x 10-4 | 0.12 | ||
| IL-10 C→A | 30 (51) | 22 (42) | 1.4 (0.65–3.3) | 0.4 | 12 (38) | 13 (44) | 0.9 (0.3–2.7) | 1.0 | 0.82 (0.7–2.1) | 0.42 | 1.0 | 0.62 | ||
Values for patients and controls are number (%) of individuals with the given genotype.
pcorr, probability from the χ2 test, corrected for multiple testing, comparing phenotypic frequencies.
↵4-151 Norwegian patients: 110 patients and 110 controls were tested for TNF2 and DRB14-1500301, 59 patients and 53 controls for IL-10, 42 patients and 110 controls for B8.
↵4-152 British patients: 50 patients and 35 controls were tested for TNF2 , DRB14-1500301 and B8, 31 patients and 31 controls for IL-10.
↵4-150 Method for estimating combined OR and χ2 according to Wolf, modified by Haldane, as given in Tiwaris and Terasaki.25
IL-10, interleukin 10; PSC, primary sclerosing cholangitis.