Mucin gene expression in the ileal mucosa of patients with Crohn's disease (CD) and controls (CT) by in situ hybridisation
| Tissue | Probe | ||||||||||||
| Patient | Tissue | MUC1 | MUC2 | MUC3 | MUC4 | MUC5AC | MUC5B | MUC6 | MUC7 | ||||
| CD 1 | Healthy ileum | −1-150 | +++ | ++ | + | − | − | − | ND | ||||
| Involved ileum | ND | ND | ND | ND | ND | ND | ND | ND | |||||
| CD 2 | Healthy ileum | + | +++ | ++ | + | − | − | − | ND | ||||
| Involved ileum | + | +++ | ++ | +/++ | − | − | − | ND | |||||
| CD 3 | Healthy ileum | − | +++ | ++ | + | − | − | − | − | ||||
| Involved ileum | + | +++ | + | + | − | − | − | − | |||||
| CD 4 | Healthy ileum | − | ++/+++ | +/++ | + | − | − | − | ND | ||||
| Involved ileum | − | +/+++ | + | + | − | − | − | ND | |||||
| CD 5 | Healthy ileum | − | +++ | ++ | + | − | − | − | − | ||||
| Involved ileum | + | +++/++++ | ++ | +/++ | − | − | − | − | |||||
| CD 6 | Healthy ileum | + | +++ | +/++ | + | − | − | − | − | ||||
| Involved ileum | + | +/++++ | −/++++ | +/++ | − | − | − | − | |||||
| UACL+ | UACL− | UACL+ | UACL+ | UACL+ | UACL− | UACL+ | UACL− | ||||||
| CD 7 | Healthy ileum | − | ++/++++ | ++ | + | − | − | − | ND | ||||
| Involved ileum | + | ++++ | +/++ | +/++ | − | − | − | ND | |||||
| UACL+ | UACL− | UACL+ | UACL+ | UACL+ | UACL− | UACL− | ND | ||||||
| CD 8 | Healthy ileum | − | +++ | ++ | + | − | − | − | ND | ||||
| Involved ileum | + | +++/++++ | ++ | + | − | − | − | ND | |||||
| CD 9 | Healthy ileum | + | +++ | ++ | + | − | − | − | − | ||||
| Involved ileum | + | ++++ | ++ | + | − | − | − | − | |||||
| CD 10 | Healthy ileum | − | +++ | +/++ | + | − | − | − | − | ||||
| Involved ileum | + | +++ | +/++ | + | − | − | − | − | |||||
| CD 11 | Healthy ileum | − | +++ | +/++ | + | − | − | − | ND | ||||
| Involved ileum | − | +++ | +/++ | + | − | − | − | ND | |||||
| CD 12 | Involved ileum (close to U) | − | ++++ | ++ | +/++ | − | − | − | ND | ||||
| UACL+ | UACL− | UACL+ | UACL+ | UACL+ | UACL+ | UACL+ | ND | ||||||
| CD 13 | Involved ileum (close to U) | + | +++ | ++ | +/++ | − | − | − | ND | ||||
| UACL+ | UACL− | UACL+ | UACL+ | UACL+ | UACL+ | UACL+ | ND | ||||||
| CD 14 | Involved ileum (close to U) | + | +++ | + | +/++ | − | − | − | ND | ||||
| CD 15 | Involved ileum (close to U) | − | +++ | ++ | + | − | − | − | − | ||||
| CD 16 | Involved ileum (close to U) | − | +++ | ++ | +/++ | − | − | − | − | ||||
| UACL+ | UACL− | UACL+ | UACL++ | UACL++ | UACL+ | UACL+ | UACL− | ||||||
| CD 17 | Involved ileum (close to U) | + | +++ | ++ | + | − | − | − | ND | ||||
| CD 18 | Involved ileum (close to U) | + | +++ | ++ | + | − | − | − | − | ||||
| UACL+ | UACL− | UACL+ | UACL+ | UACL++ | UACL+ | UACL+ | UACL− | ||||||
| CD 19 | Involved ileum (close to U) | − | +++ | ++ | + | − | − | − | − | ||||
| CT 1–14 | Normal ileum | − (n=8) | +++ | ++ | − (n=7) | − | − | − | − | ||||
| + (n=6) | + (n=7) | ||||||||||||
↵1-150 Labelling intensity: −, absent; +, weak; ++, moderate; +++, strong; ++++, very strong.
U, ulcerations; ND, not determined; UACL, ulcer associated cell lineage.