Table 3

Immunohistochemical assessment of cyclooxygenase (COX) localisation in gastric tissue

Author COX-1 localisation COX-2 localisation Antibody used
Rainsford 199591 Not detectableSmooth muscle cells, inner circular muscle layerHuman polyclonal antibodies
Iseki 199592 Mucous neck cellsSurface mucus cellsCayman antibody
Kargman 199693 Endothelial cellsSubset of macrophagesCayman antibody
Tarnawski 199694 Surface epithelial and some glandular cellsEndothelial cells of microvessels, submucosal macrophagesCayman antibody
Tarnawski 199796 Not examinedEndothelial cells of microvessels and basement membranesCayman antibody
Davies 199797 Not examined“Superficial mucosa”“Primary rat antibody”
Donnelly 199798 Parietal cellsMyofibroblasts, endothelial cells, inflammatory mononuclear cellsCayman antibody
Schmassmann 199876 Mucous neck cellsMonocytes, macrophages, fibroblasts, endothelial cells at ulcer marginCayman antibody
Zimmermann 199899 Smooth muscle cellsSmooth muscle cells, fibroblasts, endothelial cellsDianova antibody (COX-1) Cayman antibody (COX-2)
Takahashi 1998101 Not examinedFibroblasts, mononuclear cells, macrophages, granulocytesNot specified
Fu 1999104 Not examinedMononuclear cells, myofibroblasts“Primary rat antibody”
McCarthy 1999105 Not examinedSurface epithelial cells, parietal cellsCayman antibodies
Sawaoka 1998106 Not examinedMucous neck cells, mononuclear cellsNot specified